The design of this remedy was first recorded by Gao Lian, a 16th century poet and medical scholar who was an ardent proponent of the Daoist arts of nourishing life. Gao’s book, Eight Pieces on Observing the Fundamental Principles of Life (Zunsheng bajian), is still regarded as a comprehensive source of traditional lifestyle information by Chinese physicians today. Most of the remedies in this valuable collection, however, have since become forgotten. The reissue of Shenxian Dushi Dan, which appears to be particularly useful for chronic issues in modern times, is part of the Classical Pearls commitment to revitalize some of the Daoist features of Chinese herbal medicine. More specifically, it represents the combination of two very similar remedies recorded in Gao’s chapter on “Esoteric Alchemical Remedies”, namely Dushi Dan (Enlightenment Pellet) and Shenxian Bulao Wan (Longevity Pellet of the Immortals). Shenxian Dushi Dan is a long-term recovery remedy for chronic fatigued patients that according to the source text can be taken in small amounts for 1-2 years.